Cardiologist / Clinician-researcher

Dr Jie Yu

Jie is a cardiologist and clinician-researcher with more than 15 years of clinical and academic experience across China and Australia. She completed her medical degree and PhD at Peking University, and later worked as a Consultant and Associate Professor at Peking University Third Hospital.

She relocated to Australia in 2018 to pursue cardiovascular research at the George Institute for Global Health, where she held leadership roles in major international studies, including Chair of the Endpoint Adjudication Committee for the Salt Substitute and Stroke Study (NCT02092090) and Principal Investigator for the first salt-substitute trial in rural India (Salt Substitute in India Study, NCT03909659). She later returned to clinical cardiology in Australia and undertook further training in heart failure, cardiac imaging and cardio-oncology. She is currently a Conjoint Senior Lecturer at the University of Newcastle and previously served as Co-Deputy Director of the Heart and Stroke Program at the Hunter Medical Research Institute.

A central theme of her work is delivering evidence-based, patient-centred care more effectively, particularly for people with complex conditions and those living in regional and rural communities. Her recent research reflects growing interests in telehealth models of care, cancer survivorship and precision medicine in cardiovascular disease. Her overall goal is to integrate clinical excellence, research impact and health equity to improve cardiovascular outcomes, and she is committed to teaching and mentoring junior doctors and emerging clinician-researchers.

Research interests

  • Cardio-oncology (the overlap between heart disease and cancer care)
  • Heart failure
  • Hypertension
  • Preventive cardiology
  • Health service innovation

Highlights

  • 70 peer-reviewed publications
  • First-author work in JAMA, Cardiovascular Research, ESC Heart Failure and Hypertension
  • Co-authorship in the New England Journal of Medicine and Circulation

Current projects

  • Principal Investigator, TELE-CO: a physician-led telehealth cardio-oncology service for patients in regional and rural New South Wales
  • Co-Investigator, I-HALO: improving heart failure outcomes
  • BACS study: broadening access to cardiovascular services in regional, rural and remote settings, including handheld echocardiography
  • HOPES trial: how genetics may help guide more personalised treatment for hypertension
Bennetts JD, Robson C, Weismantel-Savage A, Mani J, Yu J, Robson L, Collins NJ, Williams TD, Sverdlov AL, Ngo DTM. Evaluation of a Nurse-Pharmacist Post-Discharge Telehealth Model of Care for People With Heart Failure. Heart Lung Circ. 2026 Mar 19:S1443-9506(26)00055-7. Bennetts JD, Mahmud A, Yu J, Ngo DTM, Sverdlov AL. From signal to care: Artificial intelligence in Cardio-oncology. Trends Cardiovasc Med. 2026 Mar 25:S1050-1738(26)00042-3. Butel-Simoes LE, Albayati A, Yu J, Quirk T, Sritharan S, French M, Bennetts JD, Ngo DTM, Sverdlov AL. Tyrosine kinase inhibitors - balancing the haemostatic scales: a review of associated thrombosis and bleeding. J Thromb Thrombolysis. 2026 Feb;59(2):393-410. Nguyen TN, Yu J, Perkovic V, Jardine M, Mahaffey KW, Chow CK, Arnott C, Lindley RI. The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials. J Am Geriatr Soc. 2025 Jun;73(6):1787-1796. Nguyen TN, Yu J, Perkovic V, Arnott C, Lindley RI. REPLY: The Assessment Approach of Frailty May Influence Its Prognostic Impact Amidst Clinical Trials. J Am Geriatr Soc. 2025 Nov;73(11):3620-3621. Yang H, Yang L, Jardine MJ, Arnott C, Neuen BL, Xu K, Zhao X, Qian D, Cui B, Qiu Y, Huang Y, Yu J, Wang J, Yu S, Tan H, Huang L, Li JW, Jin J. The association between sodium-glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: a propensity-matched study. Eur J Med Res. 2024 Dec 24;29(1):621. Wang X, Shaw JE, Yu J, Jennings G, Stavreski B, Magliano D, Gill TK, Adams R, Rodgers A, Woodward M, Schlaich MP, Singleton R, Zhou B, Schutte AE. Prevalence, awareness, treatment, and control rates of hypertension in the general population of Australia: a systematic review and meta-analysis. J Hypertens. 2025 Feb 1;43(2):185-190 Zeng Q, Chang W, Zhang R, Fan H, Dou Z, Liu A, Yu J, Zhou B. Association of Cancer with Heart Failure and the Prognostic Value of NT-proBNP in Cancer Patients: Findings from the NHANES (1999–2018). Curr Oncol. 2024 Aug 26;31(9):4927-4939. (Equal corresponding author ) Yu J, Houston L, Gianacas C, Lee V, Fletcher RA, Chen AX, Arnott C. Knowledge, attitudes, and behaviors related to dietary salt intake and the acceptability of salt substitute among the Australian culturally and linguistically diverse community: An online survey. J Clin Hypertens (Greenwich). 2024 May;26(5):543-552. Zhou Z, You S, Sakamoto Y, Xu Y, Ding S, Xu W, Li W, Yu J, Wang Y, Harris K, Delcourt C, Reeves MJ, Lindley RI, Parsons MW, Woodward M, Anderson C, Du X, Pu J, Wardlaw JM, Carcel C. Covert Cerebrovascular Changes in People With Heart Disease: A Systematic Review and Meta-Analysis. Neurology. 2024 Apr 23;102(8): e209204. Yu J, Arnott C, Li Q, Di Tanna GL, Tian M, Huang L, Yin X, Zhang X, Pearson SA, Labarthe DR, Elliott P, Yan LL, Zhou B, Wu Y, Neal B. Secondary Analysis of the Salt Substitute and Stroke Study (SSaSS): Effects of Potassium-Enriched Salt on Cardiac Outcomes. Hypertension. 2024 May;81(5):1031-1040. Huang L, Li Q, Wu JH, Tian M, Yin X, Yu J, Liu Y, Zhang X, Wu Y, Paige E, Trieu K, Marklund M, Rodgers A, Neal B. The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study. J Hum Hypertens. 2024 Apr;38(4):298-306. Lee VY J, Houston L, Perkovic A, Barraclough JY, Sweeting A, Yu J, Fletcher RA, Arnott C. The Effect of Weight Loss Through Lifestyle Interventions in Patients With Heart Failure With Preserved Ejection Fraction-A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Heart Lung Circ. 2024 Feb 5:S1443-9506(23)04460-8. Jain SS, Yu J, Arnott C, Neal B, Perkovic V, Neuen BL, Jardine M, Mahaffey KW. Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial. Int J Cardiol. 2024 Jan 15;395:131444. Yu J, Sweeting AN, Gianacas C, Houston L, Lee V, Fletcher RA, Perkovic V, Li Q, Neuen BL, Berwanger O, Heerspink HJL, de Zeeuw D, Arnott C. The effects of canagliflozin in type 2 diabetes in subgroups defined by population-specific body mass index: Insights from the CANVAS Program and CREDENCE trial. Diabetes Obes Metab. 2023 Dec;25(12):3724-3735. Charytan DM, Mahaffey KW, Jardine MJ, Cannon CP, Neal B, Lambers Heerspink HJ, Agarwal R, Bakris GL, de Zeeuw D, Levin A, Pollock C, Zhang H, Zinman B, Rosenthal N, Perkovic V, Di Tanna GL, Yu J, Rogers K, Arnott C, Wheeler DC. Cardiorenal protective effects of canagliflozin in CREDENCE according to glucose lowering. BMJ Open Diabetes Res Care. 2023 Jun;11(3):e003270. Yin X, Paige E, Tian M, Li Q, Huang L, Yu J, Rodgers A, Elliott P, Wu Y, Neal B. The Proportion of Dietary Salt Replaced With Potassium-Enriched Salt in the SSaSS: Implications for Scale-Up. Hypertension. 2023 May;80(5):956-965. Zhang S, Li J, Huang Y, Yu J, Pan XF. Editorial: New mechanisms and drugs for the treatment of cardiovascular disease with diabetes. Front Cardiovasc Med. 2023 Feb 20;10:1144858. doi: 10.3389/fcvm.2023.1144858. Thout SR, Yu J, Santos JA, Hameed M, Coyle DH. Dietary intakes of hypertensive patients in rural India: Secondary outcomes of a randomised, double-blind, controlled trial. Dialogues Health. 2023 Feb 3;2:100109. ( E qu a l F ir st a u t h o r ) Zhang X, Padhi A, Wei T, Xiong S, Yu J, Ye P, Tian W, Sun H, Peiris D, Praveen D, Tian M. Community prevalence and dyad disease pattern of multimorbidity in China and India: a systematic review. BMJ Glob Health. 2022 Sep;7(9):e008880. Nu n es JC, Yu J , Arnott C, Jardine MJ, Perkovic V, Mahaffey KW.  C a n ag l i f lo z i n , m e nt al h e a l t h a d verse events a n d d ia b e t e s : Ex p l o ra t o ry a n aly s is o f t h e C RE D E N C E t r i al a n d C A N VAS P r o g ram. D ia b e tes Ob e s Me tab. 2 0 22 D ec; 2 4(1 2 ): 24 5 9 - 2 4 6 4. Yi n , X., Ro d gers, A., P e r k ovic, A., H u a n g, L., Li, K . - C ., Y u , J . , et al. E f f ec t s o f sa l t s ub s t i t u t es o n c li n i c al outco m es: a s y s t em a t ic r e v iew a n d m e t a - a n aly s is. Heart. 2022 Sep 26;108(20):1608-1615. M ar k l u n d M , T u llu F, R aj T h o u t S, Y u J , B r a d y T, A p p el LJ, N e al B , Wu JHY, G u pt a R. Es t ima t ed B e n e f i t s a n d Ri sk s of U s i n g a Re d u c e d - S o d i u m, P o t a s si u m- E n ric h ed Sa l t S ub s t i t u t e in I nd i a : A M odell i ng S tud y. H y p er te n s i o n . 2022 Oct;79(10):2188-2198. Li C, Yu J, Hockham C, Perkovic V, Neuen BL, Badve SV, Houston L, Lee VY, Barraclough JY, Fletcher RA, Mahaffey KW, Heerspink HJL, Cannon CP, Neal B, Arnott C. Canagliflozin and Atrial Fibrillation in Type 2 Diabetes Mellitus: A secondary analysis from the CANVAS Program and CREDENCE trials and meta-analysis. Diabetes Obes Metab. 2022 Oct;24(10):1927-1938. (Equal First author and corresponding author). Bernabe-Ortiz A, Trieu K, Markland M, Hy Wu J, Saavedra-Garcia L, Hart AC, Yu J, Thout SR, Miranda JJ, Webster J. The potential scalability of salt substitutes as an intervention to lower population sodium levels. Salud Publica Mex. 2022 Jun 13;64:S6-S13. Li K C , H u a n g L, Ti a n M , D i T a n n a GL, Y u J, Z h a n g X, Yin X, Liu Y, H ao Z, Zhou B , Fe n g X, Li Z , Z h a n g J, S u n J, Z h a n g Y, Z h ao Y, Z h a n g R, Yu Y, Li N , Y a n LL, La b a r t h e D R, Elli o t t P, Wu Y, N e a l B , L u n g T, Si L. C o s t - eff e c t i v e n ess o f a H o u se h o l d Sa l t S u b s t i t u t i o n In t e r ve n t ion: Fi nd i n gs Fr o m 2 0, 9 9 5 P a r t i c i p a nt s o f th e Sa l t S u b s t i tu t e a n d S t r o k e S t ud y (SSaSS). Circulation. 2022 May 17;145(20):1534-1541. Zhai Q, Duan J, Yu J, Zhang H, He X, Ma Q. Letter to the Editor:  From Target Temperature Management Trial 1 to Trial 2: Therapeutic Hypothermia for Cardiac Arrest Discredited? Ther Hypothermia Temp Manag. 2022 Feb 28. B arr a c lo u gh J Y, Yu J, F i g t r e e GA, P e r k ovic V, H e e rs p i n k H JL, N e u e n B L, C a nn on C P, M a h a ff ey KW, Sc h u t t e AE, N e a l B , Ar n ott C . C ar d iovasc u lar a n d Re n al Ou t c o m es w i t h C a n agli f l o z in i n P a t i e nt s w i t h P e r i p h e r al A r t e r y D i seas e : D a t a f r o m th e C A N VAS p r o gr a m a n d C RE D E N C E t rials. D i a b e tes O b e s Me tab. 2022 Jun;24(6):1072-1083. (E q u a l F ir s t a u t h o r ) . C h ary t an DM , Y u J , Ja r d i n e M J, C a nn o n C P, Aga r w al R, B a k ris G, Gre en e T , Levin A, P oll o c k C , P ow e N R, Ar n o t t C , M a h a f f ey KW; C RE D E N C E s tud y i n ves t ig a t o r s. P o t e nt ial E f f ec t s of Eli m i n a t ion o f t h e B lack Ra c e C o eff i c i e n t in eGFR C alc u la t io n s in t h e C RE D E N C E T r ial. C l i n J Am S o c N e p h r o l. 2 0 2 2 M ar ; 1 7(3): 3 6 1 - 3 7 3. Yu J, Li J, Leaver P J , Ar n o t t C , H u f f m a n MD , Udell JA, P e r k ovic V , M a h a f f ey KW, d e Z e e u w D , F u l c h er G, M a t t h ews D R, S h aw W, Rose nt h al N , N e a l B , Fig t r e e GA. E f f ec t s of c a n agli f l o z in o n myoca r d ial i n f arc t i o n : a p ost h o c a n aly s is of t h e C A N VA S p r o gram a n d C RE D E N C E t rial. C a rdi ov a sc Re s. 2 0 22 M ar 1 6 ; 1 1 8 (4 ) : 1 1 0 3 - 1 1 1 4 . Du an J, Z h ai Q, S h i Y, G e H , Z h e n g K , D u L, Du a n B , Yu J a n d M a Q (2 0 2 2 ). Op t imal Ti m e of C oll ap se t o R e tu r n of S p o nt a n e o u s C irc u l a t i on t o A pp ly T a rg e t e d T e m p e r a tu re M a n age m e n t f or C a r d i a c Ar r es t : A B ayesian N e tw o r k M e t a - A n aly s is. F r o n t C a r d i ov a sc Me d . 2 0 22 Jan 7 ; 8 : 7 8 4 9 1 7. (C o r r e s p o n d in g a u t h o r ) . B r ow n LJ, M e r ed i t h T, Y u J , P a t el A, N e a l B , A r n o t t C , Lim E. H e a r t Fail u r e T h e r a p ies f o r th e P r eventi o n of H ER2 -M o n oclo n al A nt i b o d y - M e d i a t e d C a r d i o t oxi c i t y: A Sy s t e m a t ic Re v iew a n d M e t a - A n a l y sis of R a nd o mi z e d T r ials. C a n cers (B a sel). 2 0 21 N ov 3 ; 1 3 (21) : 5 5 2 7. B arr a c lo u g h , J.Y. , P a t el, S. , Y u , J . , N e a l , B . , A r n ott, C . T h e Ro l e o f S o d i u m G l u c o s e C o t ra n s p o r t e r - 2 I n h i b i t o rs in A th e r o s c le r o t ic C a r d iovasc u lar D is e ase: A N arr at ive Re v iew of P o t e n t ial M e c h a n is m s. Cel l s. 2 0 2 1 O c t 9 ; 1 0(1 0 ):2 6 9 9. Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, Zhang J, Tian M, Huang L, Li Z, Yu Y, Zhao Y, Zhou B, Sun J, Liu Y, Yin X, Hao Z, Yu J, Li KC, Zhang X, Duan P, Wang F, Ma B, Shi W, Di Tanna GL, Stepien S, Shan S, Pearson SA, Li N, Yan LL, Labarthe D, Elliott P. Effect of Salt Substitution on Cardiovascular Events and Death. N Engl J Med. 2021 Sep 16;385(12):1067-1077. Li K C , Ti a n M , N e a l B , H u a n g L, Yu J , Liu Y, Yin X, Z h a n g X, Wu Y, Li N , Elli o t t P, Y a n L, La b ar t h e D , H ao Z, S h i J, Fe n g X, Z h a n g J, Z h a n g Y, Z h a n g R, Zhou B , Li Z, S u n J, Z h ao Y, Yu Y, Si L, L un g T. P r otocol f o r th e eco n o m ic eva l u a t io n of th e C h i n a Sa l t S u b s t i t ut e a n d S t r o k e S tud y (SSaSS). B M J O p e n . 2 0 2 1 J u l 2 0 ; 1 1(7): e 0 4 5 9 2 9 . B arr a c lo u gh J Y , H arm e r JA, Yu J, Fi g t r e e GA, Ar n o t t C . W h y A r e W e F o r g e t t i n g P at i e n t s w i t h P e ri p h e r al Ar t e ri a l D iseas e ? H ea r t L un g C ir c . 2 0 2 1 J u l ; 3 0(7): 9 3 9 - 9 4 2 . Yu J, Tho u t SR, Li Q, Ti a n M , M ar k l u n d M , A r n o t t C , H uff m a n M D , P r av e en D , J o h n s o n C , H u a n g L, P e tt ig r ew S, N e al B , Wu JHY. E f f ec t s o f a r edu c e d - s o d i u m a d d e d - p o t ass i u m salt s ub s t i t u t e o n b l o o d p r e s s u re in r u ral I nd i a n h y p e r t e n sive p a t i e nt s: a ra n d o mi z e d , d o ub l e b li n d , c ont r oll e d t ria l . A m J C l i n N u t r . 2 0 21 J u l 1 ; 1 1 4 (1 ) : 1 8 5 - 1 9 3. K h an SS, Hu f f man MD , H arri n g t o n K, B al d r i d ge AS, Yu J, N e a l B , Ar n o t t C , S h a h SJ. Associa t ion o f b ase l i n e d i u r et ic u s e w i t h c ar d i ovascular o ut c o m es in p a t i e nt s w i t h h e a r t f ail u r e w i t h p r e serv e d e j ec t ion f r ac t i o n : A sec o n d ary a n aly s is f r o m TO P C A T . J C ar d Fai l . 2 0 21 J u l; 2 7(7) : 8 1 6 - 8 1 8. Yu J, A r n o t t C , N e u en B L, H e e rs p ri n k H L, M a h a ff ey KW, C a nn o n C P, K h a n SS, B al d ri d ge A S , S h ah SJ, Hu a n g Y, Li C , Fig t r e e GA, P e r k ovic V, Ja rd i n e M J , N e a l B , H uff m a n M D . C ar d iovasc u lar a n d r e n al outco m es w i t h c a n agli f l o z in ac c o rd i n g t o b aseline d i u r e t ic u s e : a po st h oc a n aly s is f r o m th e C A N VAS P r o gram. E S C H ea r t Fai l . 2 0 21 A p r ; 8 ( 2): 1 4 8 2 - 1 4 9 3 . Yu J, Z h o u Z, M a h a f f ey KW, M a t t h e w s D R, N e u en B L, H e e r s p i n k H JL, J a r d i n e M J , Li J, P e r k ovic V, N e a l B , Ar n o t t C . An ex p lo r a t i o n of t h e h eter o g e n ei t y in eff e c t s of SGL T 2 i nh i b i t i o n on c a r d iovasc u lar a n d al l - c a u se m o r t ali t y in t h e E M P A - REG O U T C OME, C A N VAS P r og r am, D ECLA R E - TI M I 5 8 , a n d C RE D E N C E t rials. I n t J C a r d i o l . 2 0 2 1 F e b 1 ; 3 2 4 : 1 6 5 - 1 7 2. Li C , Z h o u Z , N e u en B L, Yu J , H u a n g Y, Y ou n g T, Li J , Li L , P e r k o v ic V , J a r d i n e M J , K e a y L , M a r k oul l i M , R o se nt h a l N , C a p u a n o G , Y av i n Y , N e a l B , A r n o t t C . S o d i u m - g l u c o s e c o - t ra n s p o rt e r- 2 i nh i b i t io n a n d o c u l a r o u t c om es i n p a t ie n t s w i t h t y p e 2 d ia b e t e s: A s y s t e m a t i c r e v ie w a n d me t a - a n a l y s is. D i a b e tes O b e s Me t a b . 202 1 J a n ; 2 3 (1 ): 25 2 - 25 7. H u a n g L, Yu J, N e a l B , Liu Y, Yin X, H ao Z, W u Y, Y a n LL, Wu JH, J o s h i R, S h i J, Fe n g X, Z h a n g J, Z h a n g Y, Z h a n g R, Zhou B , Li Z, S u n J, Z h ao Y, Y u Y, P e ars o n SA, C h en Z, Ti a n M . Feasi b il i t y a n d vali d i t y of u s i n g d e a t h s u rveill a n c e d a t a a n d Smar t VA f or f act a n d c a u se of d e a t h i n c li n i c al t rials i n r u ral Ch i n a: a s ub s tud y o f t h e C h i n a sa l t s ub s t i t u t e a n d s t r o k e s t u d y (SSaSS). J E p id em i o l C o mm un i ty H ea l t h . 2 0 20 D ec 7 : j ec h - 2 0 2 0 - 2 1 4 0 6 3 . ( E qu a l F ir st a u t h o r ) . T h out SR, Yu J, Ti a n M , H uf f man M D , A r n o t t C , Li Q, D evars e tt y P, J o h n son C , P e tt i g r e w S, N e a l B , Wu JHY. Rati o n a le, d esig n , a n d b asel i n e c h arac t e r i s t i c s of t h e Sa l t S ub s t i t u t e in In d ia S t u d y (SSiIS ) : T h e p r ot ocol f o r a d o ub l e -b l i n d e d , ra n d o m i z e d- c ont r o l led t rial. J C l i n H y p e r te n s ( G r ee nwi c h ). 2 0 20 A u g ; 2 2(8): 1 5 0 4 - 1 5 1 2 . (E qu a l F ir s t a u t h o r). H u a n g L , T i a n M , Y u J , Li Q, L iu Y , Yi n X , W u JH, M ar k l un d M , W u Y, Li N , El l io t t P , Y a n L L, L a b ar t h e D R , H a o Z, S h i J , Fe n g X , Z h a n g J , Z h a n g Y , Z h a n g R, Z h o u B , Li Z , S u n J , Z h a o Y, Y u Y, N e a l B . I n t e r i m ef f e c t s o f s a l t s ub s t i tu t io n on u ri n a ry e l e c t r o l y t es a n d b loo d p r es s u r e i n t h e C h i n a S a lt S u b s t i tut e a n d S t r oke S t u d y ( S S a SS ). A m H e a r t J . 2 0 2 0 M a r; 2 2 1 : 1 3 6 - 14 5. 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Associa t i o n of P o si t ive Ai r w ay P r ess u r e w i t h C a r d iovasc u lar E ve nt s a n d D e a t h i n A du l t s W i t h Sl e ep A pn e a : A Sy s t em a t ic Re v iew a n d M e t a - a n aly s is. J A M A . 2 0 1 7 J u l 1 1 ; 3 1 8(2 ) : 1 5 6-166 . Yu J, H an JL, Wa n g GS, G u o LJ, Gao W. Se r u m t o t al b ili r ub in levels a n d d i s e a se sever i t y in p a t i e nt s w i t h s t a b le c o r o n ary ar t e r y d iseas e . H e r z . 2 0 1 7 J u n ; 4 2(4): 4 0 3 - 4 1 0 . Yu J, Z h o u B , Y u H , H an J, C u i M , Z h a n g F, Wa n g G, G u o L, Gao W. Assoc i a t ion b e t w e e n p lasma A D A M T S - 7 leve l s a n d severi t y of d ise a se in p a t i e n t s w i t h s t a b le o b s t r u c t ive c o r o n ary a r t e r y d i s e a se. Me di c in e (B a l t i m o r e ). 2 0 16 N ov ; 9 5 ( 48 ):e 5 5 2 3. Yu J, H an J, M a o J, G u o L, G a o W. 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